Pathguide: the pathway resource list
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Full Record: BRENDA  
Short NameBRENDA
Full NameBRaunschweig ENzyme DAtabase
Last ObservedFebruary 19th, 2017
DescriptionBRENDA is a database of enzymes. It is based on EC number and contains much information about each particular enzyme including reaction and specificity, enzyme structure, post-translational modification, isolation/preparation, stability and cross references to structure databanks. Information about a chemical reaction is extensive, but some of it is in free-text form. Data is also complemented by text-mining data in AMENDA and FRENDA. geneXplain offers a subscription version of BRENDA that has more features than the free version (
Sample Data URL 
Data SourcePrimary
AvailabilityFree to academic users
PubMed ArticlesBRENDA, enzyme data and metabolic information.
Schomburg I, Chang A, Schomburg D.
Nucleic Acids Res. 2002 Jan 1;30(1):47-9.

BRENDA: a resource for enzyme data and metabolic information.
Schomburg I, Chang A, Hofmann O, Ebeling C, Ehrentreich F, Schomburg D.
Trends Biochem Sci. 2002 Jan;27(1):54-6.

Review of the BRENDA Database.
Pharkya P, Nikolaev EV, Maranas CD.
Metab Eng. 2003 Apr;5(2):71-3.

BRENDA, the enzyme database: updates and major new developments.
Schomburg I, Chang A, Ebeling C, Gremse M, Heldt C, Huhn G, Schomburg D.
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D431-3.

BRENDA, AMENDA and FRENDA: the enzyme information system in 2007.
Barthelmes J, Ebeling C, Chang A, Schomburg I, Schomburg D.
Nucleic Acids Res. 2007 Jan;35(Database issue):D511-4.

BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009.
Chang A, Scheer M, Grote A, Schomburg I, Schomburg D.
Nucleic Acids Res. 2008 Nov 4.

The BRENDA Tissue Ontology (BTO): the first all-integrating ontology of all organisms for enzyme sources.
Gremse M, Chang A, Schomburg I, Grote A, Scheer M, Ebeling C, Schomburg D.
Nucleic Acids Res. 2011 Jan;39(Database issue):D507-13.

BRENDA, the enzyme information system in 2011.
Scheer M, Grote A, Chang A, Schomburg I, Munaretto C, Rother M, Sohngen C, Stelzer M, Thiele J, Schomburg D
Nucleic Acids Res. 2011 Jan;39(Database issue):D670-6.

Development of a classification scheme for disease-related enzyme information.
Sohngen C, Chang A, Schomburg D.
BMC Bioinformatics. 2011 Aug 9;12:329.

BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA.
Schomburg I, Chang A, Placzek S, Sohngen C, Rother M, Lang M, Munaretto C, Ulas S, Stelzer M, Grote A, Scheer M, Schomburg D
Nucleic Acids Res. 2013 Jan;41(Database issue):D764-72.

BRENDA in 2015: exciting developments in its 25th year of existence.
Chang A, Schomburg I, Placzek S, Jeske L, Ulbrich M, Xiao M, Sensen CW, Schomburg D.
Nucleic Acids Res. 2015 Jan;43(Database issue):D439-46.

BRENDA in 2017: new perspectives and new tools in BRENDA.
Placzek S, Schomburg I, Chang A, Jeske L, Ulbrich M, Tillack J, Schomburg D.
Nucleic Acids Res. 2017 Jan 4;45(D1):D380-D388.

Types of DataMetabolic Pathways
Types of ToolsText mining
Genes / Proteins: 82,568
Pathways: 169
Last Content Update: July 1st, 2017
Major OrganismsArabidopsis thaliana, Escherichia coli, Bos taurus, Rattus norvegicus, Homo sapiens, Saccharomyces cerevisiae, Mus musculus, Bacillus subtilis
Relative Popularity499
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"Pathguide: the pathway resource list" is maintained by Gary Bader1.
The website was originally created by Michael Cary 2 and was significantly updated and redesigned by Vuk Pavlovic1.
Thanks to Emek Demir for the Pathguide name.

1. Bader Lab
2. Sander Group

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